Archive - Bioinformatics Research Collective

Summary: Optimal Trade-Off Control in Machine Learning-Based Library Design for AAV-Mediated Gene Therapies

Introduction Adeno-associated virus (AAV)-mediated gene therapy holds significant promise for treating monogenic disorders of the central nervous system…

Oct 30, 2024 •

Primer: Non-Linear Dimensionality Reduction Techniques for Single-Cell Transcriptomics

Overview Due to low coverage in high-throughput sequencing experiments, dimensionality reduction techniques are commonly applied towards single-cell…

Oct 2, 2024 •

December 2023

Primer: Genome Assembly

Overview Genome assembly refers to the process of accurately constructing a contiguous representation of nucleotides based on a collection of smaller…

Dec 18, 2023 •

January 2023

Primer: Genome Sequencing

Overview Genome sequencing refers to the process of determining the exact order of the entirety of nucleotides in an organism’s genome at a single time.

Jan 11, 2023 •

September 2022

Summary: High-Throughput 5' UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

Introduction Gene therapy encompasses a set of therapeutic modalities intended to treat genetic and acquired diseases, by directly administering nucleic…

Sep 18, 2022 •

September 2021

Hello World! 👋

This is Bioinformatics Research Collective, an academic newsletter sharing my latest insights and discoveries in bioinformatics and scientific research…

Sep 29, 2021 •

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